Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 4/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.32 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370857 | 0.89 | GRM4 (0.66) | GRM4KCNH2ADORA3ADORA2AADORA1 | |
| SCHEMBL369153 | 0.88 | GRM4 (0.65) | GRM4KCNH2ADORA3ADORA2AADORA1 | |
| SCHEMBL367234 | 0.83 | GRM4 (0.74) | GRM4KCNH2FYNGRM8KDR | |
| SCHEMBL368114 | 0.82 | GRM4 (0.53) | GRM4KCNH2GRM8 | |
| SCHEMBL369428 | 0.81 | GRM4 (0.62) | GRM4KCNH2ADORA3ADORA2AADORA1 | |
| SCHEMBL12482364 | 0.77 | GRM4 (0.53) | GRM4KCNH2ADORA3ADORA2AADORA1 | |
| SCHEMBL370597 | 0.72 | GRM4 (0.57) | GRM4KCNH2ADORA3ADORA2AADORA1 | |
| SCHEMBL369775 | 0.72 | GRM4 (0.69) | GRM4KCNH2GRM8KDRMEN1 | |
| SCHEMBL370373 | 0.72 | GRM4 (0.51) | GRM4KCNH2GRM8KDRROCK2 | |
| SCHEMBL2532786 | 0.72 | GRM4 (0.76) | GRM4KCNH2FYNGRM8KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595986-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012009009-A2 | NOVEL 2-AMINO-4-PYRAZOLYL-THIAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |