Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076515 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10KMT2ATDP1 | |
| SCHEMBL3710764 | 0.82 | PTGDR2 (0.47) | KDM4EALDH1A1HSD17B10IDH1GRM1 | |
| SCHEMBL22185665 | 0.82 | IDH1 (0.52) | KDM4EALDH1A1HSD17B10IDH1KMT2A | |
| SCHEMBL3714361 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10IDH1KMT2A | |
| SCHEMBL30681975 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL26617566 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL3712461 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10IDH1KMT2A | |
| SCHEMBL24651096 | 0.78 | POLB (0.45) | ALDH1A1IDH1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12301250 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10KMT2ATDP1 | |
| SCHEMBL30719997 | 0.76 | KDM4E (0.68) | KDM4EALDH1A1HSD17B10KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393806-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | Elan Pharmaceuticals Inc. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010091310-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |