Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.46 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706053 | 0.81 | HRH4 (0.53) | HRH4SMN1; SMN2CYP2C19TRPC3TRPC7 | |
| SCHEMBL3707829 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP2C19TRPC3TRPC7NPC1 | |
| SCHEMBL606966 | 0.76 | HRH4 (0.92) | HRH4HRH3 | |
| Guanidine SCHEMBL3709856 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP2C19TRPC3TRPC7NPC1 | |
| SCHEMBL605308 | 0.75 | HRH4 (0.90) | HRH4HRH3 | |
| SCHEMBL64989 | 0.74 | MEN1 (0.59) | SMN1; SMN2CYP2C19NPC1RAB9ASLC29A1 | |
| SCHEMBL16648631 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2CYP2C19TRPC3TRPC7NPC1 | |
| Hydrochloric Acid SCHEMBL28015140 | 0.73 | MEN1 (0.58) | SMN1; SMN2CYP2C19NPC1RAB9ASLC29A1 | |
| SCHEMBL3712220 | 0.73 | HRH4 (0.55) | HRH4HRH3 | |
| SCHEMBL603945 | 0.73 | HRH4 (0.94) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094721-A1 | PIPERIDIN-PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF HISTAMINE H4 RECEPTOR | PALAU PHARMA, S. A. (ES) | 2010-08-26 | — | — | WO | disclosed |