Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9227218 | 0.88 | ALDH1A1 (0.71) | KDM4EALDH1A1HTTABL1MEN1 | |
| SCHEMBL3825804 | 0.84 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL5928677 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1HTTABL1HSD17B10 | |
| SCHEMBL29293876 | 0.82 | HPGD (0.54) | KDM4EALDH1A1ABL1HSD17B10MEN1 | |
| SCHEMBL3698033 | 0.82 | ALDH1A1 (0.58) | KDM4EALDH1A1HTTHSD17B10MEN1 | |
| SCHEMBL29441244 | 0.82 | ALDH1A1 (0.64) | KDM4EALDH1A1HTTHSD17B10MEN1 | |
| SCHEMBL22636373 | 0.82 | ALDH1A1 (0.64) | KDM4EALDH1A1HTTHSD17B10MEN1 | |
| SCHEMBL3583643 | 0.81 | ABL1 (0.53) | KDM4EALDH1A1HTTABL1HSD17B10 | |
| SCHEMBL4737582 | 0.80 | ALDH1A1 (0.50) | KDM4EALDH1A1ABL1HSD17B10TSHR | |
| SCHEMBL10364497 | 0.79 | GAA (0.65) | KDM4EALDH1A1ABL1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609674-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| WO-2012067824-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122890-A1 | Potassium Channel Modulators | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122890-A1 | Potassium Channel Modulators | KCNQ1, KCNQ2, KCNQ3 | KDM4E 854/4885ALDH1A1 2393/4885HTT 2030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.