Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 9/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470045 | 0.81 | PLAUR (0.46) | PLAURALDH1A1TSHRLMNAJAK2 | |
| SCHEMBL139476 | 0.78 | JAK2 (0.78) | JAK2 | |
| SCHEMBL141707 | 0.73 | JAK2 (0.83) | JAK2 | |
| SCHEMBL141764 | 0.73 | JAK2 (0.72) | JAK2 | |
| SCHEMBL15800325 | 0.73 | JAK2 (0.69) | PLAURALDH1A1TSHRLMNAJAK2 | |
| SCHEMBL142082 | 0.73 | JAK2 (0.66) | PLAURALDH1A1TSHRLMNAJAK2 | |
| SCHEMBL146210 | 0.72 | JAK2 (0.77) | JAK2 | |
| SCHEMBL3708816 | 0.70 | JAK2 (0.47) | PLAURALDH1A1TSHRLMNAJAK2 | |
| SCHEMBL141650 | 0.70 | JAK2 (0.55) | ALDH1A1JAK2POLBKDM4EHPGD | |
| SCHEMBL10271663 | 0.69 | JAK2 (0.59) | JAK2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |