Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAUR | Q03405 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708812 | 0.81 | PLAUR (0.50) | PLAURALDH1A1LMNATSHRJAK2 | |
| SCHEMBL140775 | 0.76 | JAK2 (0.58) | JAK2 | |
| SCHEMBL142060 | 0.76 | ALDH1A1 (0.49) | ALDH1A1LMNAXBP1JAK2MEN1 | |
| SCHEMBL146210 | 0.72 | JAK2 (0.77) | JAK2 | |
| SCHEMBL141650 | 0.71 | JAK2 (0.55) | ALDH1A1JAK2MEN1KMT2A | |
| SCHEMBL141707 | 0.70 | JAK2 (0.83) | JAK2 | |
| SCHEMBL141764 | 0.70 | JAK2 (0.72) | JAK2 | |
| SCHEMBL15800325 | 0.70 | JAK2 (0.69) | PLAURALDH1A1LMNATSHRJAK2 | |
| SCHEMBL2470725 | 0.70 | JAK2 (0.46) | LMNAJAK2MEN1KMT2A | |
| SCHEMBL142082 | 0.70 | JAK2 (0.66) | PLAURALDH1A1LMNATSHRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |