Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712242 | 0.92 | CHEK1 (0.38) | LRRK2PIK3CAPIK3CBHIF1AEPAS1 | |
| SCHEMBL3714226 | 0.91 | LRRK2 (0.37) | LRRK2PIK3CAPIK3CBHIF1AEPAS1 | |
| SCHEMBL3714505 | 0.84 | PIK3CA (0.48) | PIK3CAPIK3CBMAPTMTORCYP19A1 | |
| SCHEMBL3714534 | 0.82 | CHEK1 (0.39) | PIK3CAPIK3CBHIF1AEPAS1SYK | |
| SCHEMBL3712077 | 0.82 | ABL1 (0.39) | HIF1AEPAS1ALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL3714045 | 0.81 | CYP19A1 (0.41) | HIF1AEPAS1ALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL3711841 | 0.81 | CYP19A1 (0.42) | PIK3CAPIK3CBHIF1AEPAS1ALDH1A1 | |
| SCHEMBL3711200 | 0.81 | PRKD1 (0.41) | HIF1AEPAS1SYKCYP19A1CYP11B1 | |
| SCHEMBL3713715 | 0.81 | CYP19A1 (0.40) | HIF1AEPAS1ALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL3712208 | 0.81 | CYP3A4 (0.47) | PIK3CAPIK3CBMAPTMTORCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |