Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714226 | 0.92 | LRRK2 (0.37) | RAF1BRAFHDAC6HIF1AEPAS1 | |
| SCHEMBL3712242 | 0.90 | CHEK1 (0.38) | CHEK1RAF1BRAFHIF1AEPAS1 | |
| SCHEMBL13188771 | 0.86 | PIK3CA (0.48) | HDAC6AKT1HDAC1HDAC3HDAC2 | |
| SCHEMBL3715649 | 0.84 | HIF1A (0.38) | HDAC6HIF1AEPAS1HDAC1HDAC3 | |
| SCHEMBL13188362 | 0.84 | HDAC6 (0.44) | HDAC6HIF1AEPAS1HDAC1PIK3CA | |
| SCHEMBL3719077 | 0.83 | PRKD1 (0.42) | HIF1AEPAS1 | |
| SCHEMBL13187703 | 0.83 | PRKD1 (0.44) | HIF1AEPAS1HDAC1HDAC3HDAC2 | |
| SCHEMBL3711558 | 0.83 | CYP3A4 (0.47) | HDAC6HIF1AEPAS1AKT1HDAC1 | |
| SCHEMBL3713490 | 0.83 | HDAC6 (0.45) | HDAC6HIF1AEPAS1HDAC1PIK3CA | |
| SCHEMBL3709554 | 0.82 | LRRK2 (0.37) | RAF1BRAFHIF1AEPAS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |