Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370909 | 0.92 | PDE10A (0.85) | PDE10ATSHRNPSR1USP2MAPK1 | |
| SCHEMBL370737 | 0.82 | PDE10A (1.00) | PDE10ASMN1; SMN2PDE5APDE1BPDE4D | |
| SCHEMBL369760 | 0.80 | PDE10A (1.00) | PDE10ANPSR1ALDH1A1HPGDPDE5A | |
| SCHEMBL362925 | 0.76 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL369781 | 0.76 | PDE10A (0.73) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL7721385 | 0.73 | PDE10A (0.57) | PDE10ATSHRNPSR1USP2MAPK1 | |
| SCHEMBL364108 | 0.70 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL361700 | 0.70 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A | |
| SCHEMBL359719 | 0.70 | PDE10A (1.00) | PDE10ASMN1; SMN2PDE5APDE1BPDE4D | |
| SCHEMBL363715 | 0.70 | PDE10A (1.00) | PDE10APDE5APDE1BPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |