Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | USP2 | O75604 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370971 | 0.73 | PDE10A (1.00) | PDE10ATSHRALDH1A1USP2KMT2A | |
| SCHEMBL11888675 | 0.73 | NPC1 (0.65) | PDE10ATSHRALDH1A1USP2KMT2A | |
| SCHEMBL7721150 | 0.71 | LMNA (0.51) | TSHRALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL7721157 | 0.69 | SMN1; SMN2 (0.47) | TSHRALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7721154 | 0.69 | ALDH1A1 (0.50) | TSHRALDH1A1USP2KMT2ANPSR1 | |
| SCHEMBL23571793 | 0.68 | NPC1 (0.60) | PDE10ATSHRALDH1A1USP2KMT2A | |
| SCHEMBL12692402 | 0.67 | TSHR (1.00) | PDE10ATSHRALDH1A1USP2KMT2A | |
| SCHEMBL7726932 | 0.67 | HSD17B10 (0.53) | TSHRALDH1A1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL7721559 | 0.66 | SMN1; SMN2 (0.53) | TSHRALDH1A1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14131227 | 0.66 | SMN1; SMN2 (0.49) | TSHRALDH1A1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875765-B2 | Arylsulfonamide ethers, and methods of use thereof | WARNER-LAMBERT COMPANY (US) | 2005-04-05 | — | — | US | disclosed |
| US-6875765-B2 | Arylsulfonamide ethers, and methods of use thereof | WARNER-LAMBERT COMPANY (US) | 2005-04-05 | — | — | US | disclosed |