Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FPR1 | P21462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3705385 | 0.89 | USP7 (0.79) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3709046 | 0.88 | USP7 (0.78) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3707178 | 0.88 | USP7 (0.78) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3716480 | 0.88 | USP7 (0.78) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3714413 | 0.84 | USP7 (0.73) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3707749 | 0.83 | USP7 (0.71) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3705340 | 0.83 | MEN1 (0.78) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3707498 | 0.83 | USP7 (0.70) | USP7MEN1KMT2ARXFP1TSHR | |
| SCHEMBL3716653 | 0.82 | USP7 (0.70) | USP7MEN1KMT2ATSHRKDM4E | |
| SCHEMBL3706364 | 0.82 | USP7 (0.69) | USP7MEN1KMT2ARXFP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081783-A1 | NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2010-07-22 | — | — | WO | claimed |
| EP-2208725-A1 | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2010-07-21 | — | — | EP | claimed |
| US-20220125760-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | UNIVERSITÉ PAUL SABATIER TOULOUSE III (FR) | 2022-04-28 | — | — | US | disclosed |
| EP-3923987-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020196453-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR IL-33-RELATED DISEASES | 国立大学法人千葉大学 | 2020-10-01 | — | — | WO | disclosed |
| WO-2020165315-A1 | USE OF USP7 INHIBITORS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-08-20 | — | — | WO | disclosed |
| WO-2010081783-A1 | NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081783-A1 | NOVEL SPECIFIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS | HYBRIGENICS SA (FR) | 2010-07-22 | — | — | WO | disclosed |
| EP-2208725-A1 | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2010-07-21 | — | — | EP | disclosed |
| EP-2208725-A1 | Novel specific inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications | Hybrigenics S.A. (FR) | 2010-07-21 | — | — | EP | disclosed |