Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 9/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718158 | 0.89 | HDAC1 (0.48) | HDAC1HDAC6HDAC3HDAC2NCOR1 | |
| SCHEMBL3710406 | 0.88 | PIK3CA (0.46) | HDAC1CYP1A2CYP3A4CLK4ALDH1A1 | |
| SCHEMBL3716099 | 0.87 | FFAR1 (0.41) | HDAC1HDAC6HDAC3HDAC8ALDH1A1 | |
| SCHEMBL13188474 | 0.85 | CAMK2D (0.47) | HDAC1HDAC6HDAC3HDAC2FFAR1 | |
| SCHEMBL13188295 | 0.85 | ABCB1 (0.48) | HDAC1HDAC6HDAC3HDAC2NCOR1 | |
| SCHEMBL13188263 | 0.84 | HDAC6 (0.42) | HDAC1HDAC6HDAC3HDAC2NCOR1 | |
| SCHEMBL13187706 | 0.84 | FGFR4 (0.39) | HDAC1HDAC6HDAC3HDAC2NCOR1 | |
| SCHEMBL13188345 | 0.83 | GRM5 (0.39) | HDAC1HDAC6HDAC3HDAC2NCOR1 | |
| SCHEMBL3714241 | 0.83 | HDAC6 (0.41) | HDAC1HDAC6HDAC3HDAC2NCOR1 | |
| SCHEMBL3714333 | 0.82 | HDAC1 (0.49) | HDAC1HDAC6CYP1A2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |