Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 8/20 | 0.40 |
| ▸ | ACACA | Q13085 | 7/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | STK16 | O75716 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3699630 | 0.88 | SYK (0.35) | ACACBACACADAPK3JAK2STK16 | |
| SCHEMBL3699633 | 0.87 | SYK (0.34) | ACACBACACADAPK3JAK2STK16 | |
| SCHEMBL3706513 | 0.86 | OPRM1 (0.39) | DAPK3JAK2STK16MAP4K4PAK4 | |
| SCHEMBL3702594 | 0.86 | RAF1 (0.33) | ACACBACACAJAK2ABL1LCK | |
| SCHEMBL3700815 | 0.84 | SYK (0.37) | IGF1RDAPK3JAK2STK16MAP4K4 | |
| SCHEMBL15304351 | 0.83 | ACACB (0.39) | ACACBACACASUV39H2DAPK3JAK2 | |
| SCHEMBL3705090 | 0.83 | SYK (0.38) | DAPK3JAK2STK16MAP4K4PAK4 | |
| SCHEMBL3708347 | 0.83 | SYK (0.37) | DAPK3JAK2STK16MAP4K4PAK4 | |
| SCHEMBL1709910 | 0.82 | ACACB (0.36) | ACACBACACADAPK3JAK2STK16 | |
| SCHEMBL3709089 | 0.82 | ACACB (0.43) | ACACBACACASUV39H2CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551981-B2 | Furo[3,2-d]pyrimidine compounds | ABBVIE INC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | CDK2, DPYD, CDK3 | SIRT2 2938/4885SIRT1 2373/4885SIRT3 2802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.