Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710128 | 1.00 | DGAT1 (0.60) | DGAT1 | |
| SCHEMBL3053878 | 0.92 | DGAT1 (0.59) | DGAT1 | |
| SCHEMBL2770581 | 0.92 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL3053882 | 0.92 | DGAT1 (0.59) | DGAT1 | |
| SCHEMBL13196374 | 0.92 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL2770585 | 0.92 | DGAT1 (0.69) | DGAT1 | |
| Hydrochloric Acid SCHEMBL2771345 | 0.91 | DGAT1 (0.68) | DGAT1 | |
| Hydrochloric Acid SCHEMBL2771347 | 0.91 | DGAT1 (0.68) | DGAT1 | |
| SCHEMBL2769794 | 0.91 | DGAT1 (0.62) | DGAT1 | |
| SCHEMBL3050155 | 0.90 | DGAT1 (0.49) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393811-A1 | 4-AMINO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE DERIVATIVES | Pfizer Inc. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089686-A1 | 4-AMINO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDIN-5(6H)-ONE DERIVATIVES | PFIZER INC. (US) | 2010-08-12 | — | — | WO | disclosed |