Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711629 | 0.80 | NPC1 (0.67) | PIK3CAPIK3CGSMN1; SMN2 | |
| SCHEMBL13188391 | 0.78 | PIK3CG (0.49) | LRRK2PIK3CAPIK3CGABL1 | |
| SCHEMBL25258526 | 0.75 | LRRK2 (0.58) | LRRK2PIK3CAHTTSMN1; SMN2 | |
| SCHEMBL31114532 | 0.75 | LRRK2 (0.58) | LRRK2PIK3CAHTTSMN1; SMN2 | |
| SCHEMBL13188335 | 0.75 | PIK3CG (0.69) | LRRK2PIK3CAPIK3CGSMN1; SMN2 | |
| SCHEMBL3709559 | 0.75 | PIK3CG (0.83) | PIK3CAPIK3CGABL1 | |
| SCHEMBL3707938 | 0.75 | PIK3CG (0.64) | PIK3CAPIK3CGABL1 | |
| SCHEMBL3710994 | 0.75 | PIK3CD (0.74) | PIK3CAPIK3CGABL1 | |
| SCHEMBL13189097 | 0.74 | PIK3CG (0.60) | PIK3CAPIK3CGHTTSMN1; SMN2 | |
| SCHEMBL30697918 | 0.74 | PIK3CA (0.70) | LRRK2PIK3CAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |