Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.63 |
| ▸ | PI4KA | P42356 | 11/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 11/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.52 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31114781 | 0.88 | NPC1 (0.82) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL25259671 | 0.88 | NPC1 (0.82) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL3707950 | 0.84 | PIK3CA (0.50) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL3707953 | 0.84 | PIK3CA (0.53) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL74296 | 0.81 | RAB9A (1.00) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL3710139 | 0.80 | LRRK2 (0.56) | SMN1; SMN2PIK3CAPIK3CG | |
| SCHEMBL12928473 | 0.78 | PIK3CA (0.61) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL29970478 | 0.77 | PIK3CA (1.00) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL28617302 | 0.77 | PIK3CA (1.00) | NPC1MAPTRAB9ASMN1; SMN2TP53 | |
| SCHEMBL25834482 | 0.76 | MAPT (0.63) | NPC1MAPTRAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |