Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2605308 | 1.00 | ATM (0.40) | ATMGPR119KDM1ASLC6A9EPHX1 | |
| SCHEMBL4188987 | 0.81 | SLC6A9 (0.40) | ATMGPR119KDM1ASLC6A9 | |
| SCHEMBL2126024 | 0.80 | SLC6A9 (0.35) | GPR119KDM1ASLC6A9EPHX1KDM4E | |
| SCHEMBL2605338 | 0.79 | CHRM2 (0.40) | KDM1AEPHX1L3MBTL1 | |
| SCHEMBL2605299 | 0.79 | CHRM2 (0.40) | KDM1AEPHX1L3MBTL1 | |
| SCHEMBL2126165 | 0.78 | SLC6A9 (0.39) | ATMGPR119SLC6A9KDM4EPKM | |
| SCHEMBL2126423 | 0.78 | SLC6A9 (0.39) | ATMGPR119SLC6A9KDM4EPKM | |
| SCHEMBL2125188 | 0.78 | SLC6A9 (0.39) | ATMGPR119SLC6A9KDM4EPKM | |
| SCHEMBL2605309 | 0.77 | SLC6A9 (0.68) | SLC6A9 | |
| SCHEMBL2124901 | 0.76 | USP30 (0.38) | SLC6A9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391628-A1 | 2-AZA-BICYCLOÝ2.2.1¨HEPTANE COMPOUNDS AND USES THEREOF | AstraZeneca AB (SE) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010087762-A1 | 2-AZA-BICYCLO[2.2.1]HEPTANE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2010-08-05 | — | — | WO | disclosed |