Sugi Predict

Sugi Predict / Compounds / SCHEMBL3710644

SCHEMBL3710644

SCHEMBL3710644

C[Si](C)(C)CCOCn1nc(/C=C/c2ccc(CN3CCOCC3)cc2)c2ccc(/C=C3/C(=O)Nc4ccccc43)cc21

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PDGFRB P09619 2/20 0.42
▸ LRRK2 Q5S007 2/20 0.39
▸ PLK4 O00444 1/20 0.39
▸ FLT3 P36888 3/20 0.39
▸ PSEN1 P49768 2/20 0.39
▸ PSEN2 P49810 2/20 0.39
▸ APH1B Q8WW43 2/20 0.39
▸ NCSTN Q92542 2/20 0.39
▸ APH1A Q96BI3 2/20 0.39
▸ PSENEN Q9NZ42 2/20 0.39
▸ PAK1 Q13153 4/20 0.36
▸ ERBB2 P04626 2/20 0.36
▸ RET P07949 1/20 0.36
▸ FGFR1 P11362 1/20 0.36
▸ MAPK9 P45984 1/20 0.35
▸ MAPKAPK2 P49137 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3710646 1.00 PDGFRB (0.42) PDGFRBLRRK2PLK4FLT3PSEN1
SCHEMBL3710647 1.00 PDGFRB (0.42) PDGFRBLRRK2PLK4FLT3PSEN1
SCHEMBL3716529 0.87 PSEN1 (0.40) PDGFRBPLK4PSEN1PSEN2APH1B
SCHEMBL6525389 0.87 PSEN1 (0.40) PDGFRBPLK4PSEN1PSEN2APH1B
SCHEMBL3716528 0.87 PSEN1 (0.40) PDGFRBPLK4PSEN1PSEN2APH1B
SCHEMBL6522702 0.86 PSEN1 (0.42) PDGFRBPLK4FLT3PSEN1PSEN2
SCHEMBL6522705 0.86 PSEN1 (0.42) PDGFRBPLK4FLT3PSEN1PSEN2
SCHEMBL6522159 0.84 PSEN1 (0.40) PDGFRBPLK4FLT3PSEN1PSEN2
SCHEMBL6522157 0.84 PSEN1 (0.40) PDGFRBPLK4FLT3PSEN1PSEN2
SCHEMBL6522155 0.84 PSEN1 (0.40) PDGFRBPLK4FLT3PSEN1PSEN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8765748-B2 Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer UNIVERSITY HEALTH NETWORK (CA) 2014-07-01 — — US disclosed
US-20110065702-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER UNIVERSITY HEALTH NETWORK 2011-03-17 — — US disclosed
EP-2235004-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLMONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER University Health Network (CA) 2010-10-06 — — EP disclosed
WO-2009079767-A9 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER UNIVERSITY HEALTH NETWORK (CA) 2009-10-01 — — WO disclosed
WO-2009079767-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER UNIVERSITY HEALTH NETWORK (CA) 2009-07-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065702-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER TNNI3K, ABL1, TK1 PDGFRB 692/4885LRRK2 254/4885PLK4 464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.