Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.38 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.38 |
| ▸ | FOS | P01100 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1390033 | 0.86 | GPBAR1 (0.55) | KDM4EMAPK1RAB9AGPBAR1CYP26A1 | |
| SCHEMBL1390034 | 0.86 | GPBAR1 (0.55) | KDM4EMAPK1RAB9AGPBAR1CYP26A1 | |
| SCHEMBL1390427 | 0.82 | GPBAR1 (0.41) | MAPTALDH1A1HPGDKMT2AGPBAR1 | |
| SCHEMBL370198 | 0.80 | WNT3A (0.40) | GPBAR1 | |
| SCHEMBL370012 | 0.80 | GPBAR1 (0.57) | KDM4EMAPK1MAPTALDH1A1HPGD | |
| SCHEMBL1390267 | 0.79 | GPBAR1 (0.48) | MAPK1MAPTALDH1A1KMT2AGPBAR1 | |
| SCHEMBL1390017 | 0.77 | GPBAR1 (0.52) | KDM4EMAPTKMT2AGPBAR1IP6K1 | |
| SCHEMBL1390020 | 0.77 | GPBAR1 (0.52) | KDM4EMAPTKMT2AGPBAR1IP6K1 | |
| SCHEMBL1389577 | 0.74 | GPBAR1 (0.72) | KDM4EMAPK1RAB9AGPBAR1P4HTM | |
| SCHEMBL362321 | 0.74 | GPBAR1 (0.72) | KDM4EMAPK1RAB9AGPBAR1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |