Bicarbonate

Bicarbonate

SCHEMBL3710916

O=C([O-])[O-].[K+].[K+].c1cnc2cc3c(cc2n1)CCNCC3

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADCY6 O43306 1/20 0.44
ADCY3 O60266 1/20 0.44
ADCY9 O60503 1/20 0.44
ADCY5 O95622 1/20 0.44
ADCY8 P40145 1/20 0.44
ADCY7 P51828 1/20 0.44
ADCY2 Q08462 1/20 0.44
ADCY1 Q08828 1/20 0.44
ADCY4 Q8NFM4 1/20 0.44
DRD2 P14416 2/20 0.39
HTR2C P28335 6/20 0.35
HTR2B P41595 6/20 0.35
CHRNB2 P17787 2/20 0.35
CHRNA4 P43681 2/20 0.35
HTR2A P28223 1/20 0.35
NNMT P40261 1/20 0.35
SYK P43405 2/20 0.33
CHRNA1 P02708 1/20 0.33
ESR1 P03372 1/20 0.33
CHRNG P07510 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL3710915 1.00 ADCY6 (0.44) ADCY6ADCY3ADCY9ADCY5ADCY8
Bicarbonate SCHEMBL3710914 0.95 ADCY6 (0.42) ADCY6ADCY3ADCY9ADCY5ADCY8
SCHEMBL720637 0.87 ADCY6 (0.50) ADCY6ADCY3ADCY9ADCY5ADCY8
Hydrochloric Acid SCHEMBL722803 0.85 ADCY6 (0.48) ADCY6ADCY3ADCY9ADCY5ADCY8
Hydrochloric Acid SCHEMBL720409 0.85 ADCY6 (0.48) ADCY6ADCY3ADCY9ADCY5ADCY8
Succinic Acid SCHEMBL720125 0.83 ADCY6 (0.41) ADCY6ADCY3ADCY9ADCY5ADCY8
Succinic Acid SCHEMBL720126 0.83 ADCY6 (0.41) ADCY6ADCY3ADCY9ADCY5ADCY8
Cadaverine Tartrate SCHEMBL720160 0.81 ADCY6 (0.40) ADCY6ADCY3ADCY9ADCY5ADCY8
Cadaverine Tartrate SCHEMBL720159 0.81 ADCY6 (0.40) ADCY6ADCY3ADCY9ADCY5ADCY8
Cadaverine Tartrate SCHEMBL718876 0.81 ADCY6 (0.40) ADCY6ADCY3ADCY9ADCY5ADCY8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010096384-A2 FUSED BENZAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS TARGACEPT, INC. (US) 2010-08-26 WO disclosed