ADCY6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2657749	0.81	8/20
SCHEMBL2658721	0.74	8/20
SCHEMBL2658383	0.63	8/20
SCHEMBL2657546	0.61	8/20
SCHEMBL2657983	0.60	8/20
SCHEMBL2657082	0.74	7/20
SCHEMBL2657077	0.60	7/20
SCHEMBL1919194	0.53	7/20
SCHEMBL2653753	0.51	7/20
SCHEMBL2654576	0.51	7/20
SCHEMBL2655409	0.51	7/20
SCHEMBL2655997	0.49	7/20
SCHEMBL2656673	0.49	7/20
SCHEMBL2657984	0.64	6/20
SCHEMBL2658531	0.60	6/20
SCHEMBL2653428	0.58	6/20
SCHEMBL2653879	0.57	6/20
SCHEMBL2657305	0.52	6/20
SCHEMBL2656182	0.52	6/20
SCHEMBL2658725	0.51	6/20

Clinical trials — most relevant to ADCY6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram	PHASE1	COMPLETED
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Assessment of ADCY5-related Movement Disorders With Motion SENSors	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias	nan	COMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Clinical and Laboratory Study of Methylmalonic Acidemia	nan	RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Natural History of GACI With or Without ARHR2 or PXE	nan	UNKNOWN
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Caffeine, Genetic Variation and Athletic Performance	nan	UNKNOWN
Seven Year Update of Macular Degeneration Patients	nan	COMPLETED
Predisposition Genes in Monogenic Diabetes (DIAMONO)	nan	COMPLETED
Recurrent Acute Myocarditis Registry	nan	UNKNOWN
Inherited Reproductive Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ADCY6 binder may also engage these)

Protein	Name	Similarity
P30804	—	1.000	P30804 →
Q01341	—	1.000	Q01341 →
Q03343	—	0.999	Q03343 →
P40144	—	0.994	P40144 →
ADCY3	Adenylate cyclase type 3	0.994	landscape →
ADCY5	Adenylate cyclase type 5	0.994	landscape →
ADCY7	Adenylate cyclase type 7 (EC 4.6.1.1) (ATP py	0.994	landscape →
P51829	—	0.993	P51829 →
Q80TL1	—	0.993	Q80TL1 →
P40146	—	0.993	P40146 →
P30803	—	0.993	P30803 →
P84309	—	0.993	P84309 →
P32870	—	0.993	P32870 →
Q91WF3	—	0.992	Q91WF3 →
ADCY4	Adenylate cyclase type 4 (EC 4.6.1.1) (ATP py	0.992	landscape →
ADCY8	Adenylate cyclase type 8	0.991	landscape →
Q9DGG6	—	0.991	Q9DGG6 →
Q8VHH7	—	0.991	Q8VHH7 →
Q04400	—	0.990	Q04400 →
ADCY2	Adenylate cyclase type 2	0.990	landscape →
P21932	—	0.990	P21932 →
P97490	—	0.989	P97490 →
O54853	—	0.989	O54853 →
ADCY9	Adenylate cyclase type 9	0.989	landscape →
P26769	—	0.989	P26769 →
Q9TUI4	—	0.989	Q9TUI4 →
Q29450	—	0.989	Q29450 →
P98999	—	0.988	P98999 →
P51830	—	0.988	P51830 →
Q9VW60	—	0.986	Q9VW60 →