Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364249 | 0.76 | AKT1 (0.43) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL2964669 | 0.75 | KDM4E (0.49) | RAB9ASMN1; SMN2NPC1TP53LMNA | |
| SCHEMBL10987043 | 0.72 | KDM4E (0.44) | RAB9ANPC1TP53LMNAKDM4E | |
| SCHEMBL3702792 | 0.72 | AKT1 (0.42) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL3702794 | 0.72 | AKT1 (0.56) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL11035817 | 0.72 | KDM4E (0.49) | RAB9ASMN1; SMN2NPC1TP53LMNA | |
| SCHEMBL2968050 | 0.71 | ALDH1A1 (0.39) | LMNAKDM4EMAPTPDE10AALDH1A1 | |
| SCHEMBL2970170 | 0.71 | PTGS1 (0.36) | RAB9ASMN1; SMN2NPC1TP53LMNA | |
| SCHEMBL10982300 | 0.70 | PDE10A (0.57) | RAB9ASMN1; SMN2NPC1TP53LMNA | |
| SCHEMBL868954 | 0.70 | KDM4E (0.49) | SMN1; SMN2PKMLMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |