Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709425 | 0.90 | LMNA (0.46) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL3720718 | 0.88 | LMNA (0.41) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL18528183 | 0.85 | KMT2A (0.48) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL3716189 | 0.83 | LMNA (0.46) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL20206898 | 0.83 | LMNA (0.46) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL3716897 | 0.82 | KDM4E (0.47) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL3710227 | 0.81 | LMNA (0.48) | LMNAPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL13188830 | 0.81 | LMNA (0.48) | LMNAPIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL3714245 | 0.81 | KDM4E (0.51) | LMNAKDM4EALDH1A1PIK3CAPIK3CB | |
| SCHEMBL3715312 | 0.80 | PIK3CA (0.47) | LMNAALDH1A1PIK3CAPIK3CBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |