Sugi Predict

Sugi Predict / Compounds / SCHEMBL3711355

SCHEMBL3711355

SCHEMBL3711355

C[Si](C)(C)CCOCn1nc(/C=C/c2ccncc2)c2ccc(/C=C3/C(=O)Nc4ccc(Br)cc43)cc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PLK4 O00444 3/20 0.41
▸ PDGFRB P09619 1/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ MAP1LC3B Q9GZQ8 1/20 0.38
▸ PDE4A P27815 1/20 0.37
▸ PDE4B Q07343 1/20 0.37
▸ PDE4C Q08493 1/20 0.37
▸ PDE4D Q08499 1/20 0.37
▸ PLK1 P53350 1/20 0.36
▸ RPS6KA3 P51812 1/20 0.35
▸ RET P07949 1/20 0.35
▸ RAF1 P04049 2/20 0.34
▸ PIK3C3 Q8NEB9 1/20 0.34
▸ PTPN1 P18031 2/20 0.34
▸ LRRK2 Q5S007 1/20 0.33
▸ PTPN2 P17706 1/20 0.33
▸ PSEN1 P49768 1/20 0.33
▸ PSEN2 P49810 1/20 0.33
▸ APH1B Q8WW43 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3711358 1.00 PLK4 (0.41) PLK4PDGFRBMEN1KMT2AMAP1LC3B
SCHEMBL6522705 0.90 PSEN1 (0.42) PLK4PDGFRBMEN1KMT2APLK1
SCHEMBL6522702 0.90 PSEN1 (0.42) PLK4PDGFRBMEN1KMT2APLK1
SCHEMBL6526547 0.89 PLK4 (0.44) PLK4PDGFRBMEN1KMT2AMAP1LC3B
SCHEMBL6526542 0.89 PLK4 (0.44) PLK4PDGFRBMEN1KMT2AMAP1LC3B
SCHEMBL6521269 0.84 PSEN1 (0.46) PLK4PDGFRBMEN1KMT2APLK1
SCHEMBL6531323 0.84 PSEN1 (0.46) PLK4PDGFRBMEN1KMT2APLK1
SCHEMBL6521276 0.84 PSEN1 (0.46) PLK4PDGFRBMEN1KMT2APLK1
SCHEMBL6521273 0.84 PSEN1 (0.46) PLK4PDGFRBMEN1KMT2APLK1
SCHEMBL6522159 0.82 PSEN1 (0.40) PLK4PDGFRBMEN1KMT2APLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8765748-B2 Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer UNIVERSITY HEALTH NETWORK (CA) 2014-07-01 — — US disclosed
US-20110065702-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER UNIVERSITY HEALTH NETWORK 2011-03-17 — — US disclosed
EP-2235004-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLMONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER University Health Network (CA) 2010-10-06 — — EP disclosed
WO-2009079767-A9 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER UNIVERSITY HEALTH NETWORK (CA) 2009-10-01 — — WO disclosed
WO-2009079767-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER UNIVERSITY HEALTH NETWORK (CA) 2009-07-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065702-A1 INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER TNNI3K, ABL1, TK1 PLK4 464/4885PDGFRB 692/4885MEN1 3149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.