Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16462754 | 0.90 | NPBWR1 (0.49) | NPBWR1MCHR1POLBGRIN2BLMNA | |
| SCHEMBL16463383 | 0.82 | NPBWR1 (0.49) | NPBWR1MCHR1POLBGRIN2BKMT2A | |
| SCHEMBL28792753 | 0.80 | SLC6A4 (0.43) | KMT2AALDH1A1HIF1AADRA2APNMT | |
| SCHEMBL25570743 | 0.79 | BCHE (0.56) | BCHEACHEBACE1KDM4ESMN1; SMN2 | |
| SCHEMBL28694553 | 0.79 | NPBWR1 (0.44) | NPBWR1MCHR1POLBGRIN2BLMNA | |
| SCHEMBL5608590 | 0.78 | BCHE (0.59) | POLBGRIN2BLMNAKMT2ABCHE | |
| SCHEMBL28128093 | 0.77 | NPBWR1 (0.51) | NPBWR1MCHR1POLBGRIN2BLMNA | |
| SCHEMBL16464079 | 0.76 | POLB (0.76) | POLBGRIN2BLMNAKMT2ABCHE | |
| SCHEMBL25145693 | 0.75 | SLC6A4 (0.53) | BCHEACHEBACE1CXCR3 | |
| SCHEMBL27868868 | 0.75 | KCNJ1 (0.51) | LMNAKMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393814-A1 | PYRROLOPYRIMIDINYL AXL KINASE INHIBITORS | SuperGen, Inc. (US) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090764-A1 | PYRROLOPYRIMIDINYL AXL KINASE INHIBITORS | SUPERGEN, INC. (US) | 2010-08-12 | — | — | WO | disclosed |