Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3507481 | 0.84 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EHDAC1MAPTHTT | |
| SCHEMBL16213311 | 0.83 | KDM4E (0.47) | SMN1; SMN2KDM4EMAPTPKMPOLB | |
| SCHEMBL14779720 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EHDAC1MAPTHTT | |
| SCHEMBL13632447 | 0.81 | CYP2C9 (0.50) | KDM4EHDAC1HDAC6MAPTKMT2A | |
| SCHEMBL745029 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2KDM4EHDAC1MAPTHTT | |
| SCHEMBL15926181 | 0.80 | HDAC1 (0.50) | KDM4EHDAC1HDAC6MAPTHTT | |
| SCHEMBL22972298 | 0.79 | NAMPT (0.49) | HDAC1KMT2ACYP11B2HCAR2 | |
| SCHEMBL13999418 | 0.79 | DYRK1A (0.49) | SMN1; SMN2KDM4EHDAC1 | |
| SCHEMBL17695593 | 0.78 | CYP11B2 (0.47) | SMN1; SMN2KDM4EHDAC6MAPTKMT2A | |
| SCHEMBL19323052 | 0.77 | CYP11B2 (0.40) | SMN1; SMN2KDM4EHDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |