Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | HPGD | P15428 | 8/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | FUBP1 | Q96AE4 | 1/20 | 0.60 |
| ▸ | KLK7 | P49862 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.59 |
| ▸ | CASP1 | P29466 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | CASP7 | P55210 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718168 | 0.81 | ALDH1A1 (0.69) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL3278779 | 0.81 | ALDH1A1 (0.81) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL31560205 | 0.80 | ALDH1A1 (0.67) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL1718604 | 0.80 | ALDH1A1 (1.00) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL14478852 | 0.79 | TP53 (0.78) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL3278834 | 0.78 | ALDH1A1 (0.64) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL1717963 | 0.76 | ALDH1A1 (0.98) | ALDH1A1ALOX15MEN1KMT2AKDM4E | |
| SCHEMBL1720090 | 0.75 | KDM4E (0.85) | ALDH1A1ALOX15L3MBTL1KDM4EHPGD | |
| SCHEMBL8291153 | 0.74 | ALDH1A1 (0.64) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 | |
| SCHEMBL1719135 | 0.74 | KLK7 (0.68) | ALDH1A1ALOX15MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | claimed |
| EP-2214485-A1 | METHODS FOR TREATMENT OF CANCER | Minerva Biotechnologies Corp. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |
| WO-2009042815-A1 | METHODS FOR TREATMENT OF CANCER | MINERVA BIOTECHNOLOGIES CORP. (US) | 2009-04-02 | — | — | WO | disclosed |