Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212993 | 0.82 | PIK3CA (0.54) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL2946432 | 0.80 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL3711646 | 0.79 | PIK3CA (0.52) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL3252983 | 0.79 | PIK3CA (0.55) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL3128211 | 0.78 | PIK3CA (0.50) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL8214637 | 0.78 | PIK3CA (0.60) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL13188706 | 0.78 | PIK3CA (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL8216906 | 0.77 | PIK3CA (0.71) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL13188708 | 0.75 | PIK3C3 (0.61) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 | |
| SCHEMBL14436388 | 0.73 | PIK3CA (0.77) | PIK3CAPIK3CGPIK3CDPIK3CBPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |