Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | PIP4K2A | P48426 | 4/20 | 0.52 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711646 | 0.88 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL8214637 | 0.87 | PIK3CA (0.60) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL3128211 | 0.87 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL8216906 | 0.85 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL13188706 | 0.85 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL3711642 | 0.82 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL2946432 | 0.81 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL13188708 | 0.80 | PIK3C3 (0.61) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB | |
| SCHEMBL13154322 | 0.80 | PIK3CG (0.76) | PIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL3252983 | 0.80 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CGPIK3C3PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820665-B2 | Imidazopyridazine inhibitors of PI3 kinase for cancer treatment | AMGEN INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820665-B2 | Imidazopyridazine inhibitors of PI3 kinase for cancer treatment | AMGEN INC. (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2010100144-A1 | FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE | MERCK SERONO S.A. (CH) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009085230-A1 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090163489-A1 | Inhibitors of PI3 kinase | AMGEN INC. | 2009-06-25 | — | — | US | disclosed |
| US-20090163489-A1 | Inhibitors of PI3 kinase | AMGEN INC. | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163489-A1 | Inhibitors of PI3 kinase | PIK3CA, PIK3CD, PIK3CG | PIK3CA 1/4885PIK3CD 2/4885PIK3CG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.