Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LDLR | P01130 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757226 | 0.85 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8295724 | 0.85 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL6626390 | 0.83 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL27985278 | 0.82 | CYP1A2 (0.65) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL25512994 | 0.81 | MAP4K4 (0.58) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL1756573 | 0.81 | HTT (0.57) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| Methyl Alcohol SCHEMBL20590058 | 0.81 | MAP4K4 (0.55) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL8295736 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| Hydrochloric Acid SCHEMBL25193229 | 0.80 | MAP4K4 (0.57) | PDE4APDE4BPDE4CPDE4DMAP4K4 | |
| SCHEMBL652235 | 0.80 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100606-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2010-09-10 | — | — | WO | disclosed |