Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.47 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712652 | 0.90 | TBK1 (0.53) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL1284534 | 0.88 | TBK1 (0.63) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL1284739 | 0.86 | TBK1 (0.51) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL1284793 | 0.86 | TBK1 (0.49) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL1284349 | 0.85 | TBK1 (0.48) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL1284580 | 0.83 | TBK1 (0.68) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL15163134 | 0.82 | TBK1 (0.54) | TBK1PDPK1NUAK1ULK1IKBKE | |
| SCHEMBL1284417 | 0.78 | KDM4E (0.51) | KDM4E | |
| SCHEMBL15163440 | 0.77 | TBK1 (0.50) | TBK1PDPK1JAK2TYK2RPS6KA3 | |
| SCHEMBL3389382 | 0.76 | TBK1 (0.80) | TBK1PDPK1NUAK1ULK1IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |