Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | PRKDC | P78527 | 3/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357715 | 0.85 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL359707 | 0.80 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL362463 | 0.78 | PIK3CD (0.44) | PIK3CDPIK3CACYP3A4TNF | |
| SCHEMBL369833 | 0.71 | PIK3CD (0.75) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL370831 | 0.71 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2392521 | 0.70 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2392907 | 0.70 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2395627 | 0.69 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL13885982 | 0.69 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL2397815 | 0.69 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593455-A1 | PURINE COMPOUNDS SELECTIVE FOR I3 P110 DELTA, AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007493-A1 | PURINE COMPOUNDS SELECTIVE FOR ΡI3Κ P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |