Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.34 |
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711705 | 0.86 | CYP11B1 (0.41) | CYP11B1CYP11B2ACE2ACEMMP1 | |
| SCHEMBL7381299 | 0.83 | CYP11B1 (0.43) | CYP11B1CYP11B2ACE2ACE | |
| SCHEMBL22654375 | 0.81 | ACE2 (0.36) | CYP11B1CYP11B2ACE2ACEMMP1 | |
| SCHEMBL3704205 | 0.80 | CYP11B1 (0.42) | CYP11B1CYP11B2ACE2ACEALDH1A1 | |
| SCHEMBL3715232 | 0.80 | CYP11B1 (0.39) | CYP11B1CYP11B2ACE2ACE | |
| SCHEMBL7375020 | 0.80 | CYP11B1 (0.39) | CYP11B1CYP11B2ACE2ACE | |
| SCHEMBL3714337 | 0.79 | CYP11B1 (0.41) | CYP11B1CYP11B2ACE2ACECYP2C9 | |
| SCHEMBL3681437 | 0.79 | ACE2 (0.48) | CYP11B1CYP11B2ACE2ACECYP3A4 | |
| SCHEMBL3710371 | 0.79 | CYP11B1 (0.41) | CYP11B1CYP11B2ACE2ACE | |
| SCHEMBL3715181 | 0.79 | ACE2 (0.43) | CYP11B1CYP11B2ACE2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093804-A1 | ACE2 INHIBITORS FOR REDUCING GASTROINTESTINAL ADVERSE EFFECTS OF CYTOTOXIC AGENTS | ORE PHARMACEUTICALS, INC. (US) | 2010-08-19 | — | — | WO | claimed |
| WO-2009049022-A1 | METHOD FOR TREATMENT OF PANCREATITIS | ORE PHARMACEUTICALS INC. (US) | 2009-04-16 | — | — | WO | claimed |
| EP-3717077-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (DE) | 2020-10-07 | — | — | EP | disclosed |