Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.42 |
| ▸ | WNT1 | P04628 | 5/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | MOK | Q9UQ07 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188506 | 0.91 | GSK3B (0.45) | GSK3BDYRK1AWNT1JAK1MOK | |
| SCHEMBL3714558 | 0.90 | JAK1 (0.49) | GSK3BDYRK1AJAK1 | |
| SCHEMBL3713032 | 0.85 | MTOR (0.40) | MOKMAPK14HIF1AEPAS1HRH3 | |
| SCHEMBL13188418 | 0.84 | JAK1 (0.53) | GSK3BDYRK1AJAK1ADORA3HIF1A | |
| SCHEMBL3712780 | 0.83 | ACP1 (0.49) | MOKHIF1AEPAS1 | |
| SCHEMBL3713942 | 0.82 | HRH3 (0.43) | GSK3BDYRK1AWNT1MAPK14HIF1A | |
| SCHEMBL3718978 | 0.81 | HDAC1 (0.46) | GSK3BDYRK1AWNT1ABL1MAPK14 | |
| SCHEMBL13188509 | 0.81 | GSK3B (0.46) | GSK3BDYRK1AWNT1JAK1ABL1 | |
| SCHEMBL3719071 | 0.80 | MAPK1 (0.49) | MOK | |
| SCHEMBL3717690 | 0.78 | HRH3 (0.44) | GSK3BDYRK1AMAPK14HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |