Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712170 | 0.89 | MAPK1 (0.52) | HRH3MAPK1SMN1; SMN2 | |
| SCHEMBL13187713 | 0.88 | HDAC1 (0.44) | HRH3HIF1AEPAS1CD274 | |
| SCHEMBL3709590 | 0.85 | HIF1A (0.43) | HRH3MTORMAPK14HIF1AEPAS1 | |
| SCHEMBL3713942 | 0.84 | HRH3 (0.43) | HRH3MTORMAPK14HIF1AEPAS1 | |
| SCHEMBL3713032 | 0.82 | MTOR (0.40) | HRH3MTORMAPK14HIF1AEPAS1 | |
| SCHEMBL3713019 | 0.78 | GSK3B (0.42) | HRH3MAPK14HIF1AEPAS1GSK3B | |
| SCHEMBL17075531 | 0.77 | HRH3 (0.61) | HRH3HIF1AEPAS1MAPK1SMN1; SMN2 | |
| SCHEMBL3711052 | 0.76 | MAPK1 (0.48) | MAPK1SMN1; SMN2 | |
| SCHEMBL3712780 | 0.76 | ACP1 (0.49) | HIF1AEPAS1 | |
| SCHEMBL3714232 | 0.76 | HDAC1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |