Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 11/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890473 | 0.84 | NFE2L2 (0.50) | NFE2L2TRPA1RELANPC1ALDH1A1 | |
| SCHEMBL3715365 | 0.81 | NFE2L2 (0.41) | NFE2L2TRPA1NPC1ALDH1A1CYP1A2 | |
| SCHEMBL4890465 | 0.81 | NFE2L2 (0.46) | NFE2L2TRPA1RELANPC1ALDH1A1 | |
| SCHEMBL23457275 | 0.80 | NFE2L2 (0.56) | NFE2L2CYP1A2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3716196 | 0.79 | NFE2L2 (0.39) | NFE2L2TRPA1NPC1ALDH1A1CYP1A2 | |
| SCHEMBL15050711 | 0.79 | NFE2L2 (0.62) | NFE2L2TRPA1RELANPC1RAB9A | |
| SCHEMBL14416278 | 0.79 | NFE2L2 (0.62) | NFE2L2TRPA1RELANPC1RAB9A | |
| SCHEMBL29374409 | 0.79 | NFE2L2 (0.62) | NFE2L2TRPA1RELANPC1RAB9A | |
| SCHEMBL256659 | 0.79 | NFE2L2 (0.62) | NFE2L2TRPA1RELANPC1RAB9A | |
| SCHEMBL4889042 | 0.79 | NFE2L2 (0.45) | NFE2L2TRPA1RELANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273147-A1 | SUBSTITUTED SPIROLACTAMS, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES | Bayer Aktiengesellschaft (DE) | 2023-11-08 | — | — | EP | claimed |
| CN-115380211-A | Refining process and refined product | 日本水产株式会社 | 2022-11-22 | — | — | CN | claimed |
| CN-112867706-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2021-05-28 | — | — | CN | claimed |
| CN-102026980-A | Isoquinolinone derivatives as NK3 antagonists | LUNDBECK & CO AS H | 2011-04-20 | — | — | CN | claimed |
| WO-2010131145-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | claimed |
| WO-2010131146-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | claimed |
| WO-2010131147-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | claimed |
| CN-101679276-A | Isoquinolinone derivatives as nk3 antagonists | LUNDBECK & CO AS H | 2010-03-24 | — | — | CN | claimed |
| US-5461074-A | Dipropargyl containing aryl/alkyl sulfur/or sulfonyl/or sulfoxide terminated aminodiol compounds are used as renin inhibitor; therpeutical | G.D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | claimed |
| US-5317039-A | Renin inhibitors with peptides | G. D. SEARLE & CO. (US) | 1994-05-31 | — | — | US | claimed |
| US-5314920-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1994-05-24 | — | — | US | claimed |
| US-5312838-A | β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1994-05-17 | — | — | US | claimed |
| US-5268391-A | Cardiovascular disorders | C. D. SEARLE & CO. (US) | 1993-12-07 | — | — | US | claimed |
| US-5246969-A | Oligopeptides as renin inhibitors | G. D. SEARLE & CO. (US) | 1993-09-21 | — | — | US | claimed |
| WO-2024101336-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | 国立大学法人京都大学 | 2024-05-16 | — | — | WO | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-0047412-A1 | Pyrazines, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1982-03-17 | — | — | EP | disclosed |
| EP-0033965-A2 | New cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-19 | — | — | EP | disclosed |
| EP-0029998-A2 | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-06-10 | — | — | EP | disclosed |