Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | AKT1 | P31749 | 9/20 | 0.42 |
| ▸ | AKT2 | P31751 | 9/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3705458 | 0.98 | USP30 (0.57) | USP30TDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10286741 | 0.85 | USP30 (0.59) | USP30TDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3707946 | 0.78 | AKT1 (0.44) | USP30AKT1AKT2 | |
| SCHEMBL13256560 | 0.73 | SMN1; SMN2 (0.55) | TDP1SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL8311588 | 0.72 | SMN1; SMN2 (1.00) | TDP1SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3706585 | 0.72 | SMN1; SMN2 (0.54) | TDP1SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL23488326 | 0.70 | SMN1; SMN2 (0.66) | USP30TDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4562661 | 0.70 | SMN1; SMN2 (0.66) | USP30TDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14446896 | 0.70 | SMN1; SMN2 (0.66) | TDP1SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL29210947 | 0.70 | SMN1; SMN2 (0.66) | USP30TDP1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-B1 | FUSED PYRIMIDINES | BAYER IP GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |