Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359556 | 0.86 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL369157 | 0.81 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL14917080 | 0.81 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL14917105 | 0.81 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL2269727 | 0.80 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL359518 | 0.79 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL14915679 | 0.79 | MET (0.52) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL2221691 | 0.79 | MET (0.51) | METPDE3APDE4CPDE4DPDE3B | |
| SCHEMBL358990 | 0.78 | MET (0.45) | METPDE10AEGFRERBB2ERBB4 | |
| SCHEMBL14916384 | 0.75 | MET (0.47) | METPDE3APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |