Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 10/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283535 | 0.91 | MET (0.38) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL173298 | 0.86 | BRD4 (0.38) | BRD4CCL2METFGFR3FGFR1 | |
| SCHEMBL13275211 | 0.85 | MET (0.41) | MET | |
| SCHEMBL360160 | 0.85 | MET (0.40) | MET | |
| SCHEMBL360629 | 0.83 | MET (0.45) | METPDE3BPDE3A | |
| SCHEMBL360609 | 0.83 | FGFR3 (0.38) | BRD4CCL2METFGFR3FGFR2 | |
| SCHEMBL2364956 | 0.79 | MET (0.40) | MET | |
| SCHEMBL359817 | 0.78 | MET (0.40) | METFGFR3FGFR1FGFR2FGFR4 | |
| SCHEMBL359990 | 0.77 | MET (0.37) | BRD4CCL2METFGFR3FGFR1 | |
| SCHEMBL162897 | 0.77 | PDE10A (0.37) | BRD4CCL2METFGFR3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | claimed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | claimed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | claimed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | disclosed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | disclosed |
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116231-A1 | TYROSINE KINASE INHIBITORS | ABL1, ERBB2, MET | MAOA 1796/4885MAOB 1465/4885BRD4 1191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.