Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903572 | 0.78 | KDM4E (0.56) | PIM1PIM2FLT3BRAFKDM4E | |
| SCHEMBL3712048 | 0.71 | CYP46A1 (0.44) | — | |
| SCHEMBL102968 | 0.68 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL19987118 | 0.68 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL102628 | 0.68 | PIM1 (1.00) | PIM1PIM2FLT3 | |
| SCHEMBL3703519 | 0.67 | MAPK14 (0.46) | PIM1PIM2BRAFKDM4E | |
| SCHEMBL4656055 | 0.66 | BRAF (0.88) | BRAF | |
| SCHEMBL30443378 | 0.66 | PIM1 (0.61) | PIM1PIM2FLT3BRAFKCNH2 | |
| SCHEMBL1923914 | 0.66 | MAPT (0.59) | BRAFKDM4E | |
| SCHEMBL3706398 | 0.65 | KDM4E (0.45) | BRAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |