Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 14/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11776811 | 0.80 | TLR8 (0.51) | KDM4ECYP17A1 | |
| SCHEMBL3713879 | 0.78 | PIM1 (0.52) | KDM4EBRAFPIM1FLT3PIM2 | |
| SCHEMBL3703519 | 0.75 | MAPK14 (0.46) | KDM4EBRAFCYP17A1PIM1PIM2 | |
| SCHEMBL8992995 | 0.74 | GPR119 (0.47) | — | |
| SCHEMBL4656055 | 0.74 | BRAF (0.88) | BRAFRAF1MAPK14 | |
| SCHEMBL3706398 | 0.73 | KDM4E (0.45) | KDM4EBRAF | |
| SCHEMBL20137287 | 0.73 | NPC1 (0.43) | KDM4E | |
| SCHEMBL3164198 | 0.72 | KDM4E (0.69) | KDM4EBRAFCYP17A1RAF1MAPK14 | |
| SCHEMBL8207947 | 0.72 | PIM1 (0.61) | KDM4EPIM1FLT3PIM2 | |
| SCHEMBL3155574 | 0.72 | KDM4E (0.69) | KDM4EBRAFCYP17A1RAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197774-B1 | THERAPY FOR ASTHMA, SKIN DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |