Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.57 |
| ▸ | MELK | Q14680 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711715 | 0.90 | ROCK2 (0.54) | ROCK2MELKROCK1MKNK1MKNK2 | |
| SCHEMBL3713988 | 0.85 | ROCK2 (0.69) | ROCK2MELKROCK1CDC42BPA | |
| SCHEMBL3714084 | 0.85 | ROCK2 (0.71) | ROCK2MELKROCK1CDC42BPA | |
| SCHEMBL3722812 | 0.82 | MELK (0.55) | ROCK2MELKROCK1MKNK1MKNK2 | |
| SCHEMBL3808763 | 0.80 | MELK (0.52) | ROCK2MELKROCK1MKNK1MKNK2 | |
| SCHEMBL3723065 | 0.77 | MKNK1 (0.49) | ROCK2MELKROCK1MKNK1MKNK2 | |
| SCHEMBL3801724 | 0.77 | HTT (0.54) | ROCK2MELKROCK1MKNK1MKNK2 | |
| SCHEMBL3714539 | 0.76 | MELK (0.56) | ROCK2MELKROCK1MKNK1MKNK2 | |
| SCHEMBL3243323 | 0.74 | ROCK2 (0.83) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3716304 | 0.74 | CTNNB1 (0.52) | ROCK2MELKROCK1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234618-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |