Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710277 | 0.94 | SCN9A (0.40) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3702771 | 0.93 | SCN9A (0.41) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3708503 | 0.92 | LPAR1 (0.45) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3709683 | 0.88 | SCN9A (0.42) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL2336149 | 0.88 | LPAR1 (0.49) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3711408 | 0.88 | LPAR1 (0.43) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3707274 | 0.87 | LPAR1 (0.42) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3705737 | 0.86 | KDM4C (0.43) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3713322 | 0.85 | LPAR1 (0.47) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3710887 | 0.85 | NR1H4 (0.48) | SCN9ASCN5ALPAR1LPAR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |