Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714396 | 0.93 | SCN9A (0.44) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3707274 | 0.93 | LPAR1 (0.42) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3708503 | 0.87 | LPAR1 (0.45) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3710277 | 0.87 | SCN9A (0.40) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3711408 | 0.86 | LPAR1 (0.43) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3705514 | 0.86 | LPAR1 (0.52) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3712572 | 0.86 | LPAR1 (0.49) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3709683 | 0.85 | SCN9A (0.42) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL3714489 | 0.85 | LPAR1 (0.43) | SCN9ASCN5ALPAR1LPAR3LPAR2 | |
| SCHEMBL2336149 | 0.83 | LPAR1 (0.49) | SCN9ASCN5ALPAR1LPAR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |