Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18651951 | 0.82 | KDM4E (0.38) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL29728641 | 0.78 | KDM4E (0.40) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL29215624 | 0.74 | GAA (0.37) | KDM4EMAPTTHRBNR1H2CHRM2 | |
| SCHEMBL3806952 | 0.73 | KDM4E (0.35) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL2884871 | 0.71 | KDM4E (0.39) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL4876240 | 0.71 | KDM4E (0.39) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL3629917 | 0.71 | KDM4E (0.39) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL31339128 | 0.71 | PARP1 (0.38) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL7970964 | 0.68 | CHRM2 (0.39) | KDM4EMAPTTHRBDDB1CRBN | |
| SCHEMBL2793465 | 0.67 | USP2 (0.37) | KDM4EMAPTTHRBDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108268-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2010-09-30 | — | — | WO | disclosed |