Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806952 | 0.75 | KDM4E (0.35) | USP2SMN1; SMN2ELANEGPR119NR1H2 | |
| SCHEMBL18651951 | 0.73 | KDM4E (0.38) | USP2SMN1; SMN2ELANEGPR119NR1H2 | |
| SCHEMBL14150258 | 0.73 | USP2 (0.34) | USP2SMN1; SMN2ELANEGPR119NR1H2 | |
| SCHEMBL7970964 | 0.72 | CHRM2 (0.39) | USP2SMN1; SMN2ELANEGPR119NR1H2 | |
| SCHEMBL28627159 | 0.71 | NR1H2 (0.39) | ELANEGPR119NR1H2CHRM2CHRM1 | |
| SCHEMBL29215624 | 0.70 | GAA (0.37) | USP2SMN1; SMN2ELANEGPR119NR1H2 | |
| SCHEMBL3505154 | 0.68 | ESR2 (0.45) | USP2SMN1; SMN2ELANEGPR119NR1H2 | |
| SCHEMBL3629917 | 0.67 | KDM4E (0.39) | ELANEGPR119CHRM2CHRM1CHRM3 | |
| SCHEMBL4876240 | 0.67 | KDM4E (0.39) | ELANEGPR119CHRM2CHRM1CHRM3 | |
| SCHEMBL3714508 | 0.67 | KDM4E (0.36) | ELANEGPR119NR1H2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-A1 | HEPATITIS B ANTIVIRAL AGENTS | Novira Therapeutics Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| EP-3010922-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-03-15 | — | — | EP | disclosed |
| US-20100168093-A1 | SUBSTITUTED 3-AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIES DE DR. ESTEVE, S.A. (ES) | 2010-07-01 | — | — | US | disclosed |
| EP-2029571-A1 | SUBSTITUTED 3 -AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128460-A1 | SUBSTITUTED 3 -AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
| EP-1849781-A1 | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments | Laboratorios del Dr. Esteve S.A. (ES) | 2007-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168093-A1 | SUBSTITUTED 3-AMINO-4 -HYDROXY PYRROLIDINES COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | PAH, HMBS, P4HA1 | USP2 3957/4885SMN1; SMN2 3667/4885ELANE 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.