Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.35 |
| ▸ | QDPR | P09417 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714736 | 1.00 | ESR2 (0.42) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3716603 | 0.82 | PDE4A (0.41) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3716599 | 0.82 | PDE4A (0.41) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27459435 | 0.78 | ACMSD (0.51) | ESR2POLQACMSDQDPRHTR2A | |
| SCHEMBL11743772 | 0.76 | ACMSD (0.53) | POLQACMSDQDPRHTR2AHSD17B1 | |
| SCHEMBL25271583 | 0.74 | HTR2C (0.51) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25224744 | 0.74 | HTR2C (0.51) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25227729 | 0.74 | HTR2C (0.51) | ESR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3715507 | 0.73 | POLQ (0.41) | PDE4APDE4BPDE4CPDE4DPOLQ | |
| SCHEMBL6114526 | 0.73 | POLQ (0.41) | PDE4APDE4BPDE4CPDE4DPOLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785494-B2 | Calcium sensing receptor modulating compounds and pharmaceutical use thereof | LEO-PHARMA A/S (DK) | 2014-07-22 | — | — | US | claimed |
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-05-24 | — | — | US | claimed |
| WO-2010136035-A2 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | claimed |
| US-8785494-B2 | Calcium sensing receptor modulating compounds and pharmaceutical use thereof | LEO-PHARMA A/S (DK) | 2014-07-22 | — | — | US | disclosed |
| US-8785494-B2 | Calcium sensing receptor modulating compounds and pharmaceutical use thereof | LEO-PHARMA A/S (DK) | 2014-07-22 | — | — | US | disclosed |
| US-8785494-B2 | Calcium sensing receptor modulating compounds and pharmaceutical use thereof | LEO-PHARMA A/S (DK) | 2014-07-22 | — | — | US | disclosed |
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| WO-2010136035-A2 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136035-A2 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129926-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | CASR, CALCR, ORAI1 | ESR2 824/4885PDE4A 352/4885PDE4B 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.