Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13188473 | 0.86 | PIK3CA (0.46) | MAPK1SMN1; SMN2DPP4PIK3CAPRKD2 | |
| SCHEMBL13188565 | 0.81 | HDAC6 (0.50) | RAB9ASMN1; SMN2PRKD2PARP1 | |
| SCHEMBL3715095 | 0.78 | CHKA (0.47) | MAPK1SMN1; SMN2PIK3CA | |
| SCHEMBL3717935 | 0.76 | MAPK1 (0.50) | MAPK1SMN1; SMN2MMP13MMP2MMP8 | |
| SCHEMBL3711313 | 0.75 | MAPK1 (0.49) | MAPK1SMN1; SMN2MMP13MMP2MMP8 | |
| SCHEMBL3716532 | 0.74 | LMNA (0.54) | LMNAMAPTTSHRMAPK1STAT3 | |
| SCHEMBL13188784 | 0.73 | HDAC1 (0.51) | — | |
| SCHEMBL3711200 | 0.73 | PRKD1 (0.41) | PIM1PIM3PRKD2 | |
| SCHEMBL14715398 | 0.72 | MAPK1 (0.65) | LMNAMAPTTSHRMAPK1STAT3 | |
| SCHEMBL3714558 | 0.72 | JAK1 (0.49) | MAPK1SMN1; SMN2DYRK1AMMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |