SCHEMBL3714903

SCHEMBL3714903

CC(C)c1[nH]nc2c(NCc3ccccc3F)nc(Cl)nc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 16/20 0.53
CCNE1 P24864 14/20 0.53
CDK1 P06493 7/20 0.51
CCNB1 P14635 6/20 0.51
CCNB2 O95067 3/20 0.51
CCNB3 Q8WWL7 3/20 0.51
CDK5 Q00535 13/20 0.49
AURKA O14965 1/20 0.49
CCNE2 O96020 1/20 0.49
CDK5R1 Q15078 4/20 0.46
CDK9 P50750 4/20 0.46
CCNT1 O60563 3/20 0.46
CDK7 P50613 3/20 0.46
CCNH P51946 2/20 0.46
CDK4 P11802 3/20 0.45
CCNA2 P20248 3/20 0.45
CCND1 P24385 3/20 0.45
CDK6 Q00534 1/20 0.45
ADORA3 P0DMS8 1/20 0.43
ADORA1 P30542 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3717319 0.86 CDK2 (0.69) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL2904692 0.84 CDK1 (0.65) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL30332119 0.81 CDK2 (0.48) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL3716186 0.81 CDK2 (0.60) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL3714904 0.81 ADORA3 (0.41) CDK1CCNB1CCNB2CCNB3ADORA3
SCHEMBL30332492 0.79 CDK2 (0.46) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL3723172 0.76 CDK2 (0.55) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL3725146 0.76 CDK2 (0.79) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL30332415 0.75 CCNE1 (0.44) CDK2CCNE1CDK1CCNB1CCNB2
SCHEMBL3719061 0.74 CDK2 (0.59) CDK2CCNE1CDK1CCNB1CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010139288-A1 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS C3 BIO GMBH (DE) 2010-12-09 WO disclosed