Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.72 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252216 | 0.84 | IMPDH2 (1.00) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL15058583 | 0.76 | IMPDH2 (0.43) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL27040501 | 0.76 | IMPDH2 (0.43) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL21050856 | 0.76 | IMPDH2 (0.43) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL29751463 | 0.76 | IMPDH2 (0.43) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL10921238 | 0.76 | IMPDH2 (0.72) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL3240722 | 0.76 | POLB (0.53) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL30709993 | 0.76 | IMPDH2 (0.43) | IMPDH2AXLCLK1DYRK1AKDM4E | |
| SCHEMBL29569821 | 0.75 | CLK1 (0.54) | IMPDH2CLK1DYRK1AKDM4EPOLB | |
| SCHEMBL672509 | 0.75 | CLK1 (0.54) | IMPDH2CLK1DYRK1AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |